Question: How to determine genome wide Co-occupancy between two transcription factors? by Galaxy main
1
gravatar for yewenduo
4.1 years ago by
yewenduo60
United States
yewenduo60 wrote:

Hello:

I am currently using Galaxy to analyze several sets of ChIP-Seq datas, including those published and in house generated from my own sample.

When closely looking at two sets of bigWig file of TF binding data in UCSC genome browser, I surprisingly discovered that two of the transcription factors form well overlapped peaks in the promoter region of several genes.

Now I want to do a heat map ploting for genome wide enriched region in one transcription factor and take a look at that generated from another within the same genome X-axis see if it is also enriched. Ho can I do that?

Is there any other bioinformatic assay I could do to determine the extend of co-occupation of two transcription factors?

Thanks  in advance for answering those questions!

chip-seq • 1.4k views
ADD COMMENTlink modified 4.1 years ago by fubar1.1k • written 4.1 years ago by yewenduo60
0
gravatar for fubar
4.1 years ago by
fubar1.1k
Australia
fubar1.1k wrote:

Not galaxy main, but https://hyperbrowser.uio.no/hb/ is probably a good place to start. Failing that, you might try asking these questions to a more general bioinformatics audience such as http://seqanswers.com/

ADD COMMENTlink modified 4.1 years ago • written 4.1 years ago by fubar1.1k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 16.09
Traffic: 171 users visited in the last hour