On standard UNIX, the SIGHUP signal (kill -HUP <pid>) is used to
this kind of actions (re-read config files) on almost all daemons .
Doing a quick grep:
$ grep -ri "HUP" galaxy-central
Nothing shows up, so as Jen indicated, does not seem to be implemented
at first glance... but one could have a look at:
And handle that signal... I guess that the daemon would be "paster",
haven't found where it reads the loc files :-S